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  • Epigenetics Discoveries

    • Major Discoveries Illuminate Potential of Field ----- Timeline of Epigenetics Study

       

       

      Studies that demonstrate the effect of epigenetic factors:

       

      1.        Goldberg, A.D., C.D. Allis, and E. Bernstein, Epigenetics: a landscape takes shape.
      Cell, 2007. 128(4): p. 635-8.

      2.        Rice, J.C. and C.D. Allis, Histone methylation versus histone acetylation: new insights into epigenetic regulation. Curr Opin Cell Biol, 2001. 13(3): p. 263-73.

      3.        Kimura, A., K. Matsubara, and M. Horikoshi, A decade of histone acetylation: marking eukaryotic chromosomes with specific codes. J Biochem (Tokyo), 2005. 138(6): p. 647-62.

      4.        Brownell, J.E., et al., Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell, 1996. 84(6): p. 843-51.

      5.        Taunton, J., C.A. Hassig, and S.L. Schreiber, A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science, 1996. 272(5260): p. 408-11.

      6.        Yoder, J.A., et al., DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. J Mol Biol, 1997. 270(3): p. 385-95.

      7.        Chen, D., et al., Regulation of transcription by a protein methyltransferase.
      Science, 1999. 284(5423): p. 2174-7.

      8.        Rea, S., et al., Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature, 2000. 406(6796): p. 593-9.

      9.        Dhalluin, C., et al., Structure and ligand of a histone acetyltransferase bromodomain.
      Nature, 1999. 399(6735): p. 491-6.

      10.    Jacobson, R.H., et al., Structure and function of a human TAFII250 double bromodomain module. Science, 2000. 288(5470): p. 1422-5.

      11.    Wang, Y., et al., Human PAD4 regulates histone arginine methylation levels via demethylimination. Science, 2004. 306(5694): p. 279-83.

      12.    Cuthbert, G.L., et al., Histone deimination antagonizes arginine methylation.
      Cell, 2004. 118(5): p. 545-53.

      13.    Shi, Y., et al., Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
      Cell, 2004. 119(7): p. 941-53.

      14.    Tsukada, Y., et al., Histone demethylation by a family of JmjC domain-containing proteins.
      Nature, 2006. 439(7078): p. 811-6.

      15.    Whetstine JR. et al., Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell, 2006, 205(3): p. 467-81.

      16.    Sims, R.J., 3rd, et al., Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell, 2007. 28(4): p. 665-76.




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